Linked Life Data

6095572

Source:http://linkedlifedata.com/resource/pubmed/id/6095572

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-1-3
pubmed:abstractText
Ovariectomized ewes were infused over a period of 12 h at constant rates with different doses of the catecholoestrogen 4-hydroxyoestradiol (4-OHE2) or the primary oestrogen oestradiol (E2) via a catheter placed in the right atrium. Blood samples were drawn every hour for a total period of 48 h starting 1 h before the beginning of the steroid infusion. Luteinizing hormone (LH), 4-OHE2 and E2 concentrations were measured in these samples by specific radioimmunoassays. Infusions of low doses E2 (0.5 microgram/h) or 4-OHE2 (2 micrograms/h) caused only a suppression of LH-secretion. At doses of 1 microgram E2/h or 5 micrograms 4-OHE2/h this negative effect was followed by inconsistent elevations of plasma LH. Beyond this threshold dose, E2 at infusion rates of 2, 5 and 10 micrograms/h and 4-OHE2 at infusion rates of 10, 25 and 50 micrograms/h produced the negative effect and massive LH-surges. At still higher infusion rates (E2: 20 micrograms/h, 4-OHE2: 100 micrograms/h) lower elevations of plasma LH levels were observed. 4-OHE2 had to be infused at 4-5 times higher rates than E2 to obtain comparable plasma concentrations of either oestrogen. Under this condition the effects of 4-OHE2 and E2 were similar indicating that 4-OHE2 has the same potency as E2 at central target sites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0001-5598
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
328-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effects of continuous infusions of 4-hydroxyoestradiol and oestradiol on plasma LH-levels in the ovariectomized ewe.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't