Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-12-26
pubmed:abstractText
The neuraminidase (NA) gene from A/New Jersey (NJ)/8/76 (H1N1, formerly Hsw1 N1) strain isolated in 1976 was cloned into pBR322 and its complete nucleotide sequence was determined. The NJ8 NA gene is 1458 nucleotides long and the sequence predicted the primary structure of the NA molecule comprising of 469 amino acids with a molecular weight of 51,628. Comparison with other NA sequences of the N1 subtype strains which were isolated in 1933-1934 identified the highly variable regions at the amino-terminal stalk region and the carboxy-terminal regions. Potential glycosylation sites encoded by a 15 base-pair unit sequence are arrayed tandemly at the stalk regions. The lengths of stalk regions are highly variable because of segmental deletions in old NA genes. Possible mechanisms for such deletions are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0735-1313
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
401-13
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The complete nucleotide sequence of the influenza virus neuraminidase gene of A/NJ/8/76 strain and its evolution by segmental duplication and deletion.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't