Linked Life Data

6094943

Source:http://linkedlifedata.com/resource/pubmed/id/6094943

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-12-28
pubmed:abstractText
A study was undertaken of the interaction between liver cells and Herpes Simplex Virus (HSV) in vitro. Hepatocytes were obtained from HSV-resistant (C57/B16) and from HSV-susceptible (BALB/c, A/J, C3H) mouse strains and cultured according to standard methods. Each culture was infected with several strains of HSV-type 1 or of HSV-type 2, respectively. The multiplicity of infection was 5. The cytopathic effect was evaluated by light- and electron-microscopy. The number of infectious particles was determined using rabbit kidney or Vero cell cultures. All evaluations were made at different time intervals after infection. No difference concerning the replication rate of HSV-1 and 2 in isolated hepatocytes from resistant and susceptible mouse strains was detected. However, a marked difference was observed with respect to the production of infectious particles: HSV-1 exhibited a good multiplication rate, whereas no production of virus particles was observed with HSV-2. The data show that mice hepatocytes fail to bear the genotype for resistance to HSV infections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0106-9543
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-24
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Infection of murine hepatocyte cultures by herpes simplex virus (HSV) 1 and 2.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't