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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1985-1-2
|
| pubmed:abstractText |
Studies were undertaken to determine if cholestasis in alcoholic or viral hepatitis is related to immunologic hyperreactivity as suggested for cholestasis due to type-II drug-induced hepatitis, and evaluate possible mechanisms involved in lymphokine-induced cholestasis. Results indicate that a cholestatic factor exists in alcoholic and acute viral hepatitis. Supernatants of lymphocytes from patients with alcoholic hepatitis stimulated by an extract of alcoholic hyalin evoked a 28% +/- 7.3 SEM reduction in rat bile flow (P less than 0.03). Supernatants of lymphocytes from patients with acute viral hepatitis activated by liver-specific protein caused a reduction in rat bile flow of 24% +/- 5.9 SEM (P less than 0.03). A decrease in bile flow also occurred following injections of sera from patients with alcoholic or acute viral hepatitis. In contrast, injection of supernatants of non-stimulated lymphocytes or those from chronic active hepatitis or healthy subjects did not produce a significant change in bile flow. Supernatants of stimulated lymphocytes from tuberculin-sensitized guinea pigs caused a similar decrease in rat bile flow and reduced excretion of human secretory immunoglobulin A (IgA). Despite reductions in rat bile flow there were no alterations in liver morphology, liver plasma membrane Na-K-ATPase activity, microsomal cholesterol-7 alpha-hydroxylase activity or low-dose indocyanine green clearance during the period of observation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-2972
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
346-53
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6094201-Adult,
pubmed-meshheading:6094201-Animals,
pubmed-meshheading:6094201-Bile,
pubmed-meshheading:6094201-Cholestasis,
pubmed-meshheading:6094201-Cholesterol 7-alpha-Hydroxylase,
pubmed-meshheading:6094201-Female,
pubmed-meshheading:6094201-Guinea Pigs,
pubmed-meshheading:6094201-Hepatitis, Alcoholic,
pubmed-meshheading:6094201-Hepatitis, Viral, Human,
pubmed-meshheading:6094201-Humans,
pubmed-meshheading:6094201-Immunoglobulin A, Secretory,
pubmed-meshheading:6094201-Liver,
pubmed-meshheading:6094201-Lymphocytes,
pubmed-meshheading:6094201-Male,
pubmed-meshheading:6094201-Middle Aged,
pubmed-meshheading:6094201-Rats,
pubmed-meshheading:6094201-Rats, Inbred Strains,
pubmed-meshheading:6094201-Sodium-Potassium-Exchanging ATPase
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Studies of the influence of immunological and serological factors from patients with cholestasis due to alcoholic or viral hepatitis on biliary function in the rat.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|