Linked Life Data

6092965

Source:http://linkedlifedata.com/resource/pubmed/id/6092965

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5989
pubmed:dateCreated
1984-12-6
pubmed:abstractText
A number of proto-oncogenes have recently been localized to the chromosomal segments that are the breakpoints in the specific rearrangements noted in human malignant diseases. Moreover, rearranged forms of several proto-oncogenes have been identified in malignant cells; in several instances, the proto-oncogene has undergone an alteration as a result of a nonrandom chromosomal rearrangement. One proto-oncogene that has yet to be associated with human neoplastic disease is c-src, the cellular homologue of the transforming sequence of Rous sarcoma virus (RSV). By somatic cell hybridization, c-src has been mapped to chromosome 20, but its precise location was not determined. We have now mapped this gene by using in situ hybridization of the cloned human c-src probe to human mitotic chromosomes. We report here that the human genome contains two loci with strong homology to the coding regions of this oncogene, at 1p34-p36 and 20q12-q13. It is noteworthy that these chromosomal regions are frequently involved in the structural rearrangements observed in haematological malignant diseases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
312
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-1
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Evidence for two distinct c-src loci on human chromosomes 1 and 20.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't