Linked Life Data

6092089

Source:http://linkedlifedata.com/resource/pubmed/id/6092089

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-12-20
pubmed:abstractText
Since corticosteroids have been shown to be transferred across the human placenta, prolonged administration of these drugs during gestation could be expected to suppress the response of the neonatal adrenal gland. Plasma cortisol levels, before and 30 min after the injection of ACTH (36 micrograms/kg), were determined in six neonates who were exposed in utero to prolonged maternal administration of prednisone. The basal plasma cortisol levels of these neonates (6.15 +/- 2.57 micrograms %; mean +/- SEM) were similar to values obtained in eight healthy neonates (5.19 +/- 1.36 micrograms %). The increment of cortisol levels after ACTH stimulation (16.4 +/- 2.07 micrograms %) of the study patients was larger (P less than 0.01) than the change (10.3 +/- 0.82 micrograms %) observed in six older controls. These results indicate a normal neonatal adrenal reserve after prolonged exposure to corticosteroids during fetal life.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0340-6199
pubmed:author
pubmed:issnType
Print
pubmed:volume
142
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Adrenocortical reserve of neonates born of long-term, steroid-treated mothers.
pubmed:publicationType
Journal Article