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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1984-11-15
|
| pubmed:abstractText |
Social isolation of mice leads to changes in aminergic transmission systems. After 6 weeks of isolation, an increase of apomorphine-stimulated climbing behavior is seen, reflecting an isolation-induced dopaminergic supersensitivity. After 1-3 weeks of isolation, a decrease of clonidine sedation is detectable, suggesting the development of noradrenergic alpha 2-receptor subsensitivity. The isolation-induced changes of both drug effects are prevented by lithium given over the time of isolation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0091-3057
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
181-4
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6091155-Animals,
pubmed-meshheading:6091155-Apomorphine,
pubmed-meshheading:6091155-Biogenic Amines,
pubmed-meshheading:6091155-Clonidine,
pubmed-meshheading:6091155-Dose-Response Relationship, Drug,
pubmed-meshheading:6091155-Lithium,
pubmed-meshheading:6091155-Male,
pubmed-meshheading:6091155-Mice,
pubmed-meshheading:6091155-Motor Activity,
pubmed-meshheading:6091155-Social Isolation,
pubmed-meshheading:6091155-Synaptic Transmission
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Inhibition of isolation-induced changes in aminergic transmission by chronic lithium treatment.
|
| pubmed:publicationType |
Journal Article
|