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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1978-5-8
|
pubmed:abstractText |
The effects of BCG and wax D on methylcholanthrene (MCA) carcinogenesis in mice were studied. BCG given 8 weeks after MCA administration conferred a significant protection against carcinogenesis. When given either on the same day as MCA injection or 4 weeks after MCA, BCG slightly increased tumor incidence. Wax D provided a marked protection against tumor development when given 4 weeks after MCA. An enhanced tumor development was obtained, when wax D was administered either on the day of MCA injection or 8 weeks after MCA. These results indicated that the effects of BCG and wax D on MCA carcinogenesis varied with the timing of administration. When BCG and wax D increased the level of delayed type hypersensitivity (DTH) at the initiating time of tumor development, a protection against carcinogenesis was obtained. On the other hand, BCG and wax D enhanced tumor development, when it increased antibody formation at the time of initiation of tumor development.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0021-5031
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
435-40
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading | |
pubmed:year |
1977
|
pubmed:articleTitle |
Comparison of the mode of immunopotentiating action of BCG and wax D. II. Effect on the methylcholanthrene carcinogenesis.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|