| pubmed-article:6090267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6090267 | lifeskim:mentions | umls-concept:C0017398 | lld:lifeskim |
| pubmed-article:6090267 | lifeskim:mentions | umls-concept:C0041348 | lld:lifeskim |
| pubmed-article:6090267 | lifeskim:mentions | umls-concept:C0031800 | lld:lifeskim |
| pubmed-article:6090267 | lifeskim:mentions | umls-concept:C1517488 | lld:lifeskim |
| pubmed-article:6090267 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6090267 | pubmed:dateCreated | 1984-11-9 | lld:pubmed |
| pubmed-article:6090267 | pubmed:abstractText | The organization of the alpha- and beta-tubulin gene families in Physarum was investigated by Mendelian analysis. Restriction endonuclease-generated DNA fragments homologous to alpha- and beta-tubulin show length polymorphisms that can be used as markers for genetic mapping. Analysis of meiotic assortment among progeny of heterozygotes allowed alpha- and beta-tubulin sequence loci to be defined. There are four unlinked alpha-tubulin sequence loci (altA, altB, altC and altD) and at least three unlinked beta-tubulin sequence loci (betA, betB and betC). The alpha-tubulin loci are not linked to the beta-tubulin loci. --Segregation of tubulin sequence loci with respect to ben mutations that confer resistance to antitubulin benzimidazole drugs was used to investigate whether any members of the alpha- or beta-tubulin gene families are allelic to ben loci. The beta-tubulin sequence locus betB is allelic to the resistance locus benD, the betA locus is probably allelic to benA and the alpha-tubulin sequence locus altC may be allelic to benC. The molecular implications of benzimidazole resistance phenotypes when only one of the expressed beta-tubulin gene family members mutates to drug resistance are discussed in relation to tubulin function. | lld:pubmed |
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| pubmed-article:6090267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6090267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6090267 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6090267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6090267 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6090267 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:6090267 | pubmed:author | pubmed-author:DoveW FWF | lld:pubmed |
| pubmed-article:6090267 | pubmed:author | pubmed-author:OwensJJ | lld:pubmed |
| pubmed-article:6090267 | pubmed:author | pubmed-author:BurlandT GTG | lld:pubmed |
| pubmed-article:6090267 | pubmed:author | pubmed-author:SchedlTT | lld:pubmed |
| pubmed-article:6090267 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6090267 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:6090267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6090267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6090267 | pubmed:pagination | 143-64 | lld:pubmed |
| pubmed-article:6090267 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:6090267 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6090267 | pubmed:articleTitle | Genetics of the tubulin gene families of Physarum. | lld:pubmed |
| pubmed-article:6090267 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6090267 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6090267 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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