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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-11-9
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pubmed:abstractText |
The organization of the alpha- and beta-tubulin gene families in Physarum was investigated by Mendelian analysis. Restriction endonuclease-generated DNA fragments homologous to alpha- and beta-tubulin show length polymorphisms that can be used as markers for genetic mapping. Analysis of meiotic assortment among progeny of heterozygotes allowed alpha- and beta-tubulin sequence loci to be defined. There are four unlinked alpha-tubulin sequence loci (altA, altB, altC and altD) and at least three unlinked beta-tubulin sequence loci (betA, betB and betC). The alpha-tubulin loci are not linked to the beta-tubulin loci. --Segregation of tubulin sequence loci with respect to ben mutations that confer resistance to antitubulin benzimidazole drugs was used to investigate whether any members of the alpha- or beta-tubulin gene families are allelic to ben loci. The beta-tubulin sequence locus betB is allelic to the resistance locus benD, the betA locus is probably allelic to benA and the alpha-tubulin sequence locus altC may be allelic to benC. The molecular implications of benzimidazole resistance phenotypes when only one of the expressed beta-tubulin gene family members mutates to drug resistance are discussed in relation to tubulin function.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-378391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6196370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6221115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6244106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6294303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6308633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6380751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6688039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6780200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6802501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6819086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6825172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6831558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6833391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6865944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6877238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6893015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-6986988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-7035828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-7312039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-7464932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-845942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6090267-99245
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-64
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:6090267-Base Sequence,
pubmed-meshheading:6090267-DNA Restriction Enzymes,
pubmed-meshheading:6090267-Genes,
pubmed-meshheading:6090267-Genes, Fungal,
pubmed-meshheading:6090267-Genetic Linkage,
pubmed-meshheading:6090267-Genotype,
pubmed-meshheading:6090267-Heterozygote,
pubmed-meshheading:6090267-Meiosis,
pubmed-meshheading:6090267-Mutation,
pubmed-meshheading:6090267-Physarum,
pubmed-meshheading:6090267-Plasmids,
pubmed-meshheading:6090267-Tubulin
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pubmed:year |
1984
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pubmed:articleTitle |
Genetics of the tubulin gene families of Physarum.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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