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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1984-11-20
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pubmed:abstractText |
Madin-Darby canine kidney (MDCK) cells express a high density of binding sites (Bmax = 0.67 pmol/10(6) cells) for [3H]RO 5-4864, a peripheral-type benzodiazepine (BZD) receptor ligand. Receptor affinity (Kd = 45 nM) in MDCK cells is 30-50 fold lower than in rat kidney, but its pharmacological specificity is identical to that of peripheral-type BZD receptors in the rat kidney (PK 11195 greater than RO 5-4864 greater than diazepam = flunitrazepam greater than clonazepam). The MDCK cell line should provide a useful model system for studying the role of peripheral type BZD receptors in renal function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6090173-Animals,
pubmed-meshheading:6090173-Benzodiazepinones,
pubmed-meshheading:6090173-Cell Line,
pubmed-meshheading:6090173-Cell Membrane,
pubmed-meshheading:6090173-Convulsants,
pubmed-meshheading:6090173-Dogs,
pubmed-meshheading:6090173-Epithelium,
pubmed-meshheading:6090173-Ion Channels,
pubmed-meshheading:6090173-Kidney,
pubmed-meshheading:6090173-Kinetics,
pubmed-meshheading:6090173-Receptors, GABA-A
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pubmed:year |
1984
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pubmed:articleTitle |
Peripheral-type benzodiazepine binding sites in a renal epithelial cell line (MDCK).
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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