Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1984-9-27
|
pubmed:abstractText |
The interaction of feline leukaemia virus (FeLV) of subgroups A and C in the pathogenesis of erythroid hypoplasia in cats was studied. Weanling kittens infected with FeLV-A became permanently viraemic but remained haematologically normal over a period of 36 weeks. Similar kittens inoculated with FeLV-C, which produces erythroid hypoplasia when administered to newborn kittens, neither became viraemic nor developed the disease. However, weanling kittens inoculated with a mixture of FeLV-A and C became viraemic, first with FeLV-A and then additionally with FeLV-C, and the emergence of FeLV-C into the blood coincided with the advent of erythroid hypoplasia. When FeLV-C was inoculated into five older cats which had been viraemic with FeLV-A for several months previously, it appeared in the plasma of three of the cats and erythroid hypoplasia was diagnosed in two of these, 16-20 weeks after infection with FeLV-C. These results show that FeLV-A enhances the growth of FeLV-C in cats and overcomes their age-related resistance to FeLV-C. Also, the appearance of FeLV-C in the plasma of cats viraemic with FeLV-A indicates that erythroid hypoplasia will subsequently occur rapidly. These findings are relevant to the origin of FeLV-C isolates and their occurrence in nature.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0020-7136
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
34
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
283-8
|
pubmed:dateRevised |
2007-7-24
|
pubmed:meshHeading |
pubmed-meshheading:6088406-Anemia, Aplastic,
pubmed-meshheading:6088406-Animals,
pubmed-meshheading:6088406-Antibodies, Neoplasm,
pubmed-meshheading:6088406-Antibodies, Viral,
pubmed-meshheading:6088406-Cats,
pubmed-meshheading:6088406-Hematocrit,
pubmed-meshheading:6088406-Leukemia, Experimental,
pubmed-meshheading:6088406-Leukemia Virus, Feline,
pubmed-meshheading:6088406-Neutralization Tests,
pubmed-meshheading:6088406-Serotyping
|
pubmed:year |
1984
|
pubmed:articleTitle |
Interaction between feline leukaemia virus subgroups in the pathogenesis of erythroid hypoplasia.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|