Linked Life Data

6088238

Source:http://linkedlifedata.com/resource/pubmed/id/6088238

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1984-10-18
pubmed:abstractText
The in vivo 99mTc-RBC labelling efficiency and stability of labelling was assessed after pretinning with a high-stannous content DTPA kit (Sn DTPA) in comparison with Sn-pyrophosphate (Sn PPi) and a low-stannous DTPA kit (DTPA). The distribution in Sprague Dawley rats showed that similar fractions of administered 99mTc remained within the blood pool after pretinning with Sn DTPA and Sn PPi when equal quantities of stannous ions (15 micrograms/kg) and equal time intervals (30 min) between successive IV injections of pretinning agent and 99mTc-pertechnetate were used. Significantly lower fractions were found when DTPA (1.9 micrograms Sn2+/kg) was used for pretinning. The rate of 99mTc elution emphasises the importance of the Sn2+ concentration used, not only for labelling efficiency but also for stability of the labelling. Satisfactory intravascular activity, exceeding 80% during the first hour post-injection, was demonstrated in three volunteers after 99mTc injection, when Sn DTPA was used for pretinning. Left ventricular ejection fractions (LVEF) measured by equilibrium radionuclide angiography after pretinning with Sn DTPA in 24 patients correlated well (r = 0.98) with those obtained by contrast angiographies over a broad spectrum of values (0.14-0.72). Four repeated LVEF measurements at 45-min intervals in six additional patients at rest showed excellent reproducibility in each patient: maximum variation was less than 6%.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-6997
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
In vivo labelling of RBC with 99mTc for blood pool imaging using different stannous radiopharmaceuticals.
pubmed:publicationType
Journal Article, Comparative Study