Linked Life Data

6087990

Source:http://linkedlifedata.com/resource/pubmed/id/6087990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1984-10-19
pubmed:abstractText
Extracellular recordings from 141 rat supraoptic nucleus neurons maintained in vitro in a perfused hypothalamic explant indicated that the excitability of 85% of cells was enhanced by the addition of 10-200 microM norepinephrine (NE) and the alpha-agonist methoxamine (MOXY), but not by isoproterenol, to the perfusion medium or by pressure application. Similar responses were observed from 7 cells maintained in synaptic isolation in medium containing 15 mM Mg2+. At the lowest effective concentration (10 microM), NE and MOXY induced bursting activity without an overall increase in firing frequency; at higher concentrations an initial increase in firing frequency was followed by the appearance of phasic activity patterns. The actions of NE and MOXY were reversibly blocked by administration of the alpha-adrenergic antagonists phenoxybenzamine (1-10 microM), yohimbine (greater than 10 microM) and irreversibly blocked by prazosin (10 nM-1 microM). These observations suggest that NE has a predominantly facilitatory role to enhance the excitability and promote bursting activity in supraoptic neurosecretory neurons through an alpha-1 adrenoreceptor mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
307
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
374-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Alpha-adrenergic activation of rat hypothalamic supraoptic neurons maintained in vitro.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't