Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-9-19
pubmed:abstractText
The effects of local anaesthetics and holding potential on sodium and asymmetry currents were studied in intracellularly dialysed squid giant axons. The asymmetry currents were fractionated into their inactivating and non-inactivating components, and the charge displacements Qi and Qn of the two components were determined for pulse potentials between -20 and +40 mV. The charged local anaesthetic RAD 366, a quaternary derivative of lidocaine, applied internally at a concentration in the dialysis solution of 1 mM, did not change Qn, but reduced Qi about 3-fold. The neutral local anaesthetic benzocaine, applied externally at a concentration in the bathing solution of 1 mM, had effects very similar to RAD 366. It did not change Qn, but reduced Qi and the sodium current about 2 . 5-fold. Unlike local anaesthetics, steady membrane depolarization had essentially equal effects on Qn, Qi and sodium current. Lowering the holding potential from -98 to -60 mV for several minutes reduced all three variables to about half. Models of sodium channel voltage-gating are discussed which implicate both Qn and Qi, and which account for the selective blockage of Qi by sodium inactivation and local anaesthetics.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-1191685, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-12991237, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-233268, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-233568, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-233569, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-300786, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-356157, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-4217361, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-428306, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-428308, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-4414038, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-4541340, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-4821243, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-4824995, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-5044577, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-5346530, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-536736, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-5407037, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-591912, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6127712, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6127713, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6140679, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6247484, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6265861, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6294219, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6297572, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-6308231, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-674687, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-7061986, http://linkedlifedata.com/resource/pubmed/commentcorrection/6086917-874870
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:volume
352
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
653-68
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The effect of local anaesthetics on the components of the asymmetry current in the squid giant axon.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't