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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1978-4-17
|
| pubmed:abstractText |
A recombinant virus AA-CR19 was produced that contains RNA segments coding for one polymerase protein, the nucleoprotein and the matrix protein of cold-adapted A/Ann Arbor/6/60, but HA, NA and two other genes coding for polymerase proteins from A/Victoria/3/75. The nonstructural protein gene is probably derived from A/Ann Arbor/6/60, but may contain a spontaneous mutation. Biological characterization of AA-CR19 showed that it possesses the gene(s) responsible for cold-adaptation and temperature-sensitivity of the A/Ann Arbor/6/60 parent. At a dose of 10(7.2) TCID/50. AA-CR19 was found to be immunogenic and attenuated for seronegative volunteers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-5149
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
25-31
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:604106-Adult,
pubmed-meshheading:604106-Antibody Formation,
pubmed-meshheading:604106-Cold Temperature,
pubmed-meshheading:604106-Genes, Viral,
pubmed-meshheading:604106-Humans,
pubmed-meshheading:604106-Influenza A virus,
pubmed-meshheading:604106-Influenza Vaccines,
pubmed-meshheading:604106-RNA, Viral,
pubmed-meshheading:604106-Recombination, Genetic,
pubmed-meshheading:604106-Vaccines, Attenuated
|
| pubmed:articleTitle |
Biological, genetic and biochemical characterization of a cold-adapted recombinant A/Victoria/3/75 virus and its evaluation in volunteers.
|
| pubmed:publicationType |
Journal Article
|