Linked Life Data

6033603

Source:http://linkedlifedata.com/resource/pubmed/id/6033603

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1967-10-7
pubmed:abstractText
Two healthy men with high working capacities were injected intravenously with palmitate-1-(14)C and NaH(14)CO(3) on two occasions while they were performing strenuous exercise on a bicycle ergometer. From analysis of (14)CO(2) in expired air after injection of NaH(14)CO(3), rate constants and compartment sizes describing a three-compartment system for CO(2) were determined algebraically. These data were combined with those of a separate study in which (14)C in free fatty acids of arterial blood plasma and in expired CO(2) were measured after injection of palmitate-1-(14)C to construct an eight-compartment model with an analogue computer that described precisely the observed data in each subject. The results indicate that under these conditions almost half of the free fatty acids leaving the blood are oxidized directly (i.e., are transferred to mitochondrial oxidative sites through small intermediate compartments). The remainder enters larger compartments apart from the direct pathway; most of this fraction reenters the direct oxidative pathway within 30 min. These observations suggest that certain esterified fatty acids contained in working muscle cells are rapidly renewed. Recycling of (14)C in plasma free fatty acids and triglyceride fatty acids was substantially reduced during exercise. Values for turnover rate and extent of oxidation of free fatty acids obtained by the method of continuous intravenous infusion of palmitate-1-(14)C were similar during exercise in these two subjects to those obtained after pulse injection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
366-73
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1967
pubmed:articleTitle
Kinetic analysis of the oxidation of palmitate-1-14C in man during prolonged heavy muscular exercise.
pubmed:publicationType
Journal Article