Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
|
| pubmed:dateCreated |
1978-3-10
|
| pubmed:abstractText |
The effectiveness of intramuscular 15-methyl-prostaglandin F2alpha (15-methyl-PGF2alpha) application for therapeutic abortion was studied in 16 women during the first and second trimester (12 to 17 weeks) of pregnancy. 250 microgram 15-methyl-PGF2alpha were administered initial and at intervals of 2 hours. Of the 16 subjects, 2 aborted completely, 13 aborted incompletely and 1 failed to abort. The mean abortion time for the 15 successful abortions was 11,25 hours and the mean 15-methyl-PGF2alpha dosage 1,35 mgs. Vomiting and diarrhea were the most prevalent side effects occurring in 12 of 16 patients. No serious complications occurred. In 9 women between 7 to 13 weeks of pregnancy a single intramuscular injection of 250 microgram 15-methyl-PGF2alpha was administered 11 to 13 hours prior to vacuum aspiration. All subjects had a gradual softening and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. All subjects had a gradual softning and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. Intramuscular administration of 15-methyl-PGF2alpha appears to be an effective abortifacient. Gastro-intestinal side effects can be reduced by antiemetic and antidiarrheal agents or lowering the initial dose of 15-methyl-PGF2alpha.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Abortifacient Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Induced,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Control, Postconception,
http://linkedlifedata.com/resource/pubmed/keyword/Gastrointestinal Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy, First Trimester,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy, Second Trimester,
http://linkedlifedata.com/resource/pubmed/keyword/Prostaglandins--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Prostaglandins--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Vacuum Aspiration,
http://linkedlifedata.com/resource/pubmed/keyword/Vomiting
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0044-4197
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1356-60
|
| pubmed:dateRevised |
2008-2-11
|
| pubmed:otherAbstract |
PIP: Use of 15-methyl-prostaglandin F2 alpha to induce therapeutic abortion in 25 women is described. Repeated intramuscular (im) injections resulted in complete abortion in 2 patients, and incomplete abortion in 13 others. A 16th patient failed to abort. In 9 women in the 7-13th week of pregnancy, a single im injection induced cervical softening and dilatation before vacuum aspiration. Diarrhea and vomiting occurred in 19 patients. The authors recommend the use of anti-emetics and anti-diarrheals, or a lower initial dose, to control side effects. Evidence indicates 15-methyl-prostaglandin F2 alpha is a successful abortifacient.
|
| pubmed:meshHeading |
pubmed-meshheading:602503-Abortion, Therapeutic,
pubmed-meshheading:602503-Adolescent,
pubmed-meshheading:602503-Adult,
pubmed-meshheading:602503-Diarrhea,
pubmed-meshheading:602503-Female,
pubmed-meshheading:602503-Humans,
pubmed-meshheading:602503-Injections, Intramuscular,
pubmed-meshheading:602503-Nausea,
pubmed-meshheading:602503-Pregnancy,
pubmed-meshheading:602503-Pregnancy Trimester, First,
pubmed-meshheading:602503-Pregnancy Trimester, Second,
pubmed-meshheading:602503-Prostaglandins F, Synthetic,
pubmed-meshheading:602503-Vacuum Curettage
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
[Therapeutic induction of abortion in the 1st and 2nd trimesters with intramuscular 15-methyl-prostaglandin F2 alpha].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|