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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1978-2-18
|
| pubmed:abstractText |
The structures of tallysomycins A and B, two major components of a new antitumor antibiotic complex, have been determined. They are glycopeptide antibiotics structurally related to bleomycin: four amino acid moieties and a disaccharide fragment which are the constituents of bleomycin molecule are also present in the tallysomycins. Tallysomycins A and B contain two new amino acids and a unique amino sugar, 4-amino-4,6-dideoxy-L-talose, which have not been hitherto found in the phleomycin-bleomycin group of antibiotics. In addition tallysomycin A has an additional amino acid, L-beta-lysine, and thus a longer peptide chain than bleomycin or tallysomycin B. Tallysomycins A and B have the same terminal amine moiety, spermidine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
789-805
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:591444-Amino Acids,
pubmed-meshheading:591444-Antibiotics, Antineoplastic,
pubmed-meshheading:591444-Carbohydrates,
pubmed-meshheading:591444-Chemical Phenomena,
pubmed-meshheading:591444-Chemistry,
pubmed-meshheading:591444-Hydrolysis,
pubmed-meshheading:591444-Magnetic Resonance Spectroscopy,
pubmed-meshheading:591444-Peptide Fragments,
pubmed-meshheading:591444-Spectrophotometry, Ultraviolet
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Tallysomycin, a new antitumor antibiotic complex related to bleomycin. II. Structure determination of tallysomycins A and B.
|
| pubmed:publicationType |
Journal Article
|