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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1978-2-18
|
| pubmed:abstractText |
The unusual actinomycetes strain No. E465-94 produced a complex of new glycopeptide antibiotics tallysomycin, which was separated by CM-Sephadex chromatography into two major components, A (C68H107N21O27S2) and B (C62H95N19O26S2). They were isolated first in a copper-chelated form and showed physico-chemical properties similar to those of the bleomycin-group of antibiotics. Tallysomycin exhibited broad antibacterial and antifungal activity, and was highly active in vivo against bacterial infections in mice. Tallysomycins A and B demonstrated potent activity in the prophage induction of lysogenic bacteria.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
779-88
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:591443-Actinomycetaceae,
pubmed-meshheading:591443-Animals,
pubmed-meshheading:591443-Antibiotics, Antineoplastic,
pubmed-meshheading:591443-Antifungal Agents,
pubmed-meshheading:591443-Bacteria,
pubmed-meshheading:591443-Bacterial Infections,
pubmed-meshheading:591443-Chemistry, Physical,
pubmed-meshheading:591443-Coliphages,
pubmed-meshheading:591443-Fermentation,
pubmed-meshheading:591443-Lethal Dose 50,
pubmed-meshheading:591443-Leukemia, Experimental,
pubmed-meshheading:591443-Mice,
pubmed-meshheading:591443-Physicochemical Phenomena
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties.
|
| pubmed:publicationType |
Journal Article
|