Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1966-3-18
pubmed:abstractText
Polycystic ovaries were found in a 16-year-old female with congenital absence of vagina, male-like external genitalia, and congenital adrenal hyperplasia. Masculinization was sufficiently severe to cause the patient to be reared as a male. Biochemical studies of ovarian tissue revealed hyperactivity and an imbalance of enzyme systems concerned with steroid-hormone biosynthesis, which led to production of large amounts of androgens. The pathway towards estrogens was preserved but less efficient than normal. Urinary steroid metabolites before and after hysterectomy and bilateral salpingo-oophorectomy revealed an absence of Porter-Silber chromogens and tetrahydrocortisone. Excretion of aldosterone was normal and that of corticosterone slightly higher than normal. The patterns of urinary 17-ketosteroids, pregnanediol, pregnanetriol and pregnanetriolone were similar to those commonly seen in congenital adrenal hyperplasia with steroid 21-hydroxylase deficiency. Urinary estrogens after panhysterectomy were low, being in the post-menopausal range. The pathogenesis of polycystic ovaries and their possible contribution to masculinization are discussed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13167176, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13326986, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13411068, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13491733, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13578274, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13579311, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13583027, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13718150, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-13968788, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-14084135, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-14104775, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-14260992, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-14370714, http://linkedlifedata.com/resource/pubmed/commentcorrection/5901591-14464504
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0008-4409
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1966
pubmed:articleTitle
Polycystic ovaries associated with congenital adrenal hyperplasia.
pubmed:publicationType
Journal Article, Case Reports