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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1977-12-29
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pubmed:abstractText |
A pharmacokinetic study of 3H-labelled 7-rhamnoglycoside of 5,7,3'-trihydroxy-4'-methoxyflavone (3H-diosmine) administered both i.v. and orally, shows the great ease with which it is absorbed in digestion. A very sharp difference in elimination between the two modes of treatment must be associated with a difference in metabolism. A study of fixation confirms this conclusion. In particular the fixation on the tunica vascularis, perhaps due to a metabolite, appears relatively late. Furthermore the existence of an enterohepatic cycle assures a permanent hepatic binding.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0004-4172
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1688-91
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:579139-Animals,
pubmed-meshheading:579139-Binding Sites,
pubmed-meshheading:579139-Diosmin,
pubmed-meshheading:579139-Female,
pubmed-meshheading:579139-Flavonoids,
pubmed-meshheading:579139-Intestinal Absorption,
pubmed-meshheading:579139-Kinetics,
pubmed-meshheading:579139-Male,
pubmed-meshheading:579139-Rats,
pubmed-meshheading:579139-Tritium
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pubmed:year |
1977
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pubmed:articleTitle |
A pharmacokinetic study of 3H-diosmine.
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pubmed:publicationType |
Journal Article
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