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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1977-12-29
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pubmed:abstractText |
Mannich bases derived from a number of substituted acetophenones and propiophenones and 3-azabicyclo[3.2.2]nonane have been evaluated for antitussive activity. One of these compounds was as potent as codeine and dextromethorphan in its antitussive activity. The most potent compound of the series, 3-(3-azabicyclo[2.2.2]nonan-3-yl)-4'-benzyloxy-2-methyl propiophenone, also exhibited antimorphine activity. There was no direct correlation between the antitussive effect and antimorphine activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0004-4172
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1648-52
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:579131-Animals,
pubmed-meshheading:579131-Antitussive Agents,
pubmed-meshheading:579131-Aza Compounds,
pubmed-meshheading:579131-Bicyclo Compounds,
pubmed-meshheading:579131-Bridged Compounds,
pubmed-meshheading:579131-Cats,
pubmed-meshheading:579131-Cough,
pubmed-meshheading:579131-Mice,
pubmed-meshheading:579131-Rabbits
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pubmed:year |
1977
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pubmed:articleTitle |
Synthesis and antitussive activity of 3-azabicyclo[3.2.2]nonane derivatives.
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pubmed:publicationType |
Journal Article
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