Linked Life Data

578085

Source:http://linkedlifedata.com/resource/pubmed/id/578085

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1977-9-29
pubmed:abstractText
It has been suggested that serotonin neurons and their pathways may mediate sensitivity to nociceptive stimuli by activating the descending inhibitory mechanisms at the spinal cord. This antinociceptive effect may be induced by direct administration of serotonin into the cerebrospinal fluid pathways. The experiment is designed to demonstrate the changes in the tail-flick response latency after the intrathecal injection of serotonin. Serotonin, 100 or 200 microgram, administered into the lumbar intrathecal space, produced an analgesic effect for as long as 40 minutes. Behavioral and morphologic observations after serotonin injections showed no adverse reaction. It is assumed that serotonin molecules penetrate the spinal cord tissue and activate the antinociceptive serotonergic pathyways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-71
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Antinociceptive effect of intrathecally administered serotonin.
pubmed:publicationType
Journal Article