| pubmed-article:5780766 | pubmed:otherAbstract | PIP: (PG) Prostaglandin E1 is an active lipid in the higher long-chain fatty acid. Administered in vitro in doses of 2.5 mcg/ml it causes contractions of the isolated rat duodenum after short-term relaxation. This contraction is inhibited by anticholinergic atropine, antihistaminic bromadryl, and the antiserotonin substance lysenyl, but only in concentrations above 10 -5 M/20 ml Tyrode's solution. Therefore we cannot consider the specific effect of PGs on acetylcholine, histamine, or serotonin receptors but rather the direct effect of PGs on the smooth muscles of the duodenum and on a special receptor. In situ PG stimulates the motor activity of the rabbit stomach, the effect being manifested after a dose of 500 mcg/kg intravenously and it persists for 10 minutes. When evaluating the effect of PGs, it is important to differentiate the effect of the pharmacological solvent, ethanol. The author draws attention to the possible importance of PGs in the regulation of the digestive tract of man and animals. | lld:pubmed |
