Linked Life Data

5780766

Source:http://linkedlifedata.com/resource/pubmed/id/5780766

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1969-6-7
pubmed:keyword
pubmed:language
cze
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0009-0565
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-5
pubmed:dateRevised
2003-11-14
pubmed:otherAbstract
PIP: (PG) Prostaglandin E1 is an active lipid in the higher long-chain fatty acid. Administered in vitro in doses of 2.5 mcg/ml it causes contractions of the isolated rat duodenum after short-term relaxation. This contraction is inhibited by anticholinergic atropine, antihistaminic bromadryl, and the antiserotonin substance lysenyl, but only in concentrations above 10 -5 M/20 ml Tyrode's solution. Therefore we cannot consider the specific effect of PGs on acetylcholine, histamine, or serotonin receptors but rather the direct effect of PGs on the smooth muscles of the duodenum and on a special receptor. In situ PG stimulates the motor activity of the rabbit stomach, the effect being manifested after a dose of 500 mcg/kg intravenously and it persists for 10 minutes. When evaluating the effect of PGs, it is important to differentiate the effect of the pharmacological solvent, ethanol. The author draws attention to the possible importance of PGs in the regulation of the digestive tract of man and animals.
pubmed:meshHeading
pubmed:year
1969
pubmed:articleTitle
[Remark on the effect of prostaglandin E 1 on the smooth muscle of the digestive tract in experimental animals].
pubmed:publicationType
Journal Article, English Abstract