|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1977-6-30
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|
pubmed:abstractText |
A series of 7-substituted alkyl-thio-acylaminocephalosporins with the following general formula were prepared and tested for in vitro antibacterial activity: (formula: see text). We tried in our research to find any relationship between antibacterial activity and pharmacokinetic properties on the one hand, and chemical structure on the other. The most interesting products were also studied for their in vivo antibacterial activity in experimental acute systemic infections in the mouse.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0004-4172
|
|
pubmed:author |
pubmed-author:BianchiAA,
pubmed-author:BiasoliGG,
pubmed-author:CasabuonaFF,
pubmed-author:ConfalonieriCC,
pubmed-author:CozziPP,
pubmed-author:GalliGG,
pubmed-author:GiraldiP NPN,
pubmed-author:MeinardiGG,
pubmed-author:MolgoraGG,
pubmed-author:MontiGG,
pubmed-author:NanniniGG,
pubmed-author:SalaLL,
pubmed-author:SeverinoDD,
pubmed-author:VitaGG,
pubmed-author:de CarneriII
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
343-52
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:577150-Animals,
pubmed-meshheading:577150-Bacteria,
pubmed-meshheading:577150-Blood Proteins,
pubmed-meshheading:577150-Cephalosporins,
pubmed-meshheading:577150-Chemical Phenomena,
pubmed-meshheading:577150-Chemistry,
pubmed-meshheading:577150-Half-Life,
pubmed-meshheading:577150-Kinetics,
pubmed-meshheading:577150-Mice,
pubmed-meshheading:577150-Microbial Sensitivity Tests,
pubmed-meshheading:577150-Protein Binding,
pubmed-meshheading:577150-Serum Albumin,
pubmed-meshheading:577150-Structure-Activity Relationship
|
|
pubmed:year |
1977
|
|
pubmed:articleTitle |
New broad-spectrum alkylthio cephalosporins.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
