Linked Life Data

573044

Source:http://linkedlifedata.com/resource/pubmed/id/573044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1979-10-24
pubmed:abstractText
Thirteen cases of CNS hemangioblastoma were examined with the immunoperoxidase technique for glial fibrillary acidic protein (GFAP) to determine if there were astrocytic elements among the "stromal cells" of these tumors. In six cases, includinng two leptomeningeal hemangioblastomas, none of the stromal cells were positive on GFAP stain. Seven cases, however, showed variable presence of Gfap positive cells, including clusters of heavily lipidized cells deep within cerebellar hemangioblastomas. These GFAP positive cells were indestinguishable by other stains from interstitial or stromal cells. Thus, it appears that in at least some hemangioblastomas of the CNS parenchyma, a few or many "stromal cells" are lipidized astrocytes. All stromal cells, however, cannot be of astrocytic origin, as proposed by Jakobiec et al. (1976), in view of our six cases where no GFAP-positive cells were found in the tumors. It is suggested that cells identified as "stromal cells" of hemangioblastomas on light microscopy are a heterogeneous group of cells including astroyctic as well as other elements and that they resemble each other on ordinary stains because of the "equalizing effect" of cell lipidization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0001-6322
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-104
pubmed:dateRevised
2007-11-9
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Astrocytes in hemangioblastomas of the central nervous system and their relationship to stromal cells.
pubmed:publicationType
Journal Article