|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1976-8-2
|
|
pubmed:abstractText |
Incubation of purified frog erythrocyte membranes with beta-adrenergic agonists at 25 degrees produces relatively rapid (half-time about 10 min) desensitization (inactivation) of about 60% of the beta-adrenergic receptor binding sites. The desensitized receptors no longer bind the specific beta-adrenergic ligand (-)[3H]dihydroalprenolol. The decrease in the number of functional beta-adrenergic receptors is also manifest as a decreased ability of isoproterenol to stimulate the membrane-bound adenylate cyclase.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-1057183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-1059161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-1245597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-167023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-171653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-238972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-238988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-3725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-4357392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-4425095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-4436329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-4607368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-4827395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5723-4927674
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
73
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1494-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:5723-Adenylate Cyclase,
pubmed-meshheading:5723-Adrenergic beta-Agonists,
pubmed-meshheading:5723-Alprenolol,
pubmed-meshheading:5723-Animals,
pubmed-meshheading:5723-Cell Membrane,
pubmed-meshheading:5723-Cell-Free System,
pubmed-meshheading:5723-Dose-Response Relationship, Drug,
pubmed-meshheading:5723-Enzyme Activation,
pubmed-meshheading:5723-Erythrocytes,
pubmed-meshheading:5723-Guanosine Triphosphate,
pubmed-meshheading:5723-Isoproterenol,
pubmed-meshheading:5723-Kinetics,
pubmed-meshheading:5723-Propranolol,
pubmed-meshheading:5723-Purine Nucleotides,
pubmed-meshheading:5723-Receptors, Adrenergic,
pubmed-meshheading:5723-Structure-Activity Relationship
|
|
pubmed:year |
1976
|
|
pubmed:articleTitle |
Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
