| pubmed-article:570882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:570882 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:570882 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:570882 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:570882 | lifeskim:mentions | umls-concept:C0079866 | lld:lifeskim |
| pubmed-article:570882 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:570882 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:570882 | lifeskim:mentions | umls-concept:C0982262 | lld:lifeskim |
| pubmed-article:570882 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:570882 | pubmed:dateCreated | 1979-6-26 | lld:pubmed |
| pubmed-article:570882 | pubmed:abstractText | The effect of chronic ethanol consumption on the ability of isolated liver fractions to metabolize the carcinogen N-nitrosopyrrolidine (NPY) was examined. Microsomal fractions of treated animals exhibited increased rates of alpha-hydroxylation of NPY. Similar increases in the specific activities of aniline hydroxylase, reduced nicotinamide adenine dinucleotide phosphate cytochrome c reductase, and the specific content of cytochrome P-450 were also observed. In contrast, no differences in the specific activities of benzo(a)pyrene hydroxylase or glucose-6-phosphatase were observed. Liver postmitochondrial supernatants from ethanol-consuming animals were able to produce 5 times more mutants than did control preparations. It is concluded that alpha-hydroxylation of NPY is probably the mechanism by which NPY is converted to a mutagen and that this pathway can be induced by ethanol. | lld:pubmed |
| pubmed-article:570882 | pubmed:language | eng | lld:pubmed |
| pubmed-article:570882 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:570882 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:570882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:570882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:570882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:570882 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:570882 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:570882 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:570882 | pubmed:author | pubmed-author:HechtS SSS | lld:pubmed |
| pubmed-article:570882 | pubmed:author | pubmed-author:ChenC HCH | lld:pubmed |
| pubmed-article:570882 | pubmed:author | pubmed-author:McCoyG DGD | lld:pubmed |
| pubmed-article:570882 | pubmed:author | pubmed-author:McCoyE CEC | lld:pubmed |
| pubmed-article:570882 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:570882 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:570882 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:570882 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:570882 | pubmed:pagination | 793-6 | lld:pubmed |
| pubmed-article:570882 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:570882 | pubmed:meshHeading | pubmed-meshheading:570882-H... | lld:pubmed |
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| pubmed-article:570882 | pubmed:meshHeading | pubmed-meshheading:570882-M... | lld:pubmed |
| pubmed-article:570882 | pubmed:meshHeading | pubmed-meshheading:570882-M... | lld:pubmed |
| pubmed-article:570882 | pubmed:meshHeading | pubmed-meshheading:570882-H... | lld:pubmed |
| pubmed-article:570882 | pubmed:meshHeading | pubmed-meshheading:570882-M... | lld:pubmed |
| pubmed-article:570882 | pubmed:meshHeading | pubmed-meshheading:570882-N... | lld:pubmed |
| pubmed-article:570882 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:570882 | pubmed:articleTitle | Enhanced metabolism and mutagenesis of nitrosopyrrolidine in liver fractions isolated from chronic ethanol-consuming hamsters. | lld:pubmed |
| pubmed-article:570882 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:570882 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:570882 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:570882 | lld:pubmed |
