Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1968-7-29
pubmed:abstractText
The influence of catecholamines on growth hormone secretion has been difficult to establish previously, possibly because of the suppressive effect of the induced hyperglycemia on growth hormone concentrations. In this study, an adrenergic receptor control mechanism for human growth hormone (HGH) secretion was uncovered by studying the effects of alpha and beta receptor blockade on insulin-induced growth hormone elevations in volunteer subjects. Alpha adrenergic blockade with phentolamine during insulin hypoglycemia, 0.1 U/kg, inhibited growth hormon elevations to 30-50% of values in the same subjects during insulin hypoglycemia without adrenergic blockade. More complete inhibition by phentolamine could not be demonstrated at a lower dose of insulin (0.05 U/kg). Beta adrenergic blockade with propranolol during insulin hypoglycemia significantly enhanced HGH concentrations in paired experiments. The inhibiting effect of alpha adrenergic receptor blockade on HGH concentrations could not be attributed to differences in blood glucose or free fatty acid values; however, more prolonged hypoglycemia and lower plasma free fatty acid values may have been a factor in the greater HGH concentrations observed during beta blockade. In the absence of insulin induced hypoglycemia, neither alpha nor beta adrenergic receptor blockade had a detectable effect on HGH concentrations. Theophylline, an inhibitor of cyclic 3'5'-AMP phosphodiesterase activity, also failed to alter plasma HGH concentrations. These studies demonstrate a stimulatory effect of alpha receptors and a possible inhibitory effect of beta receptors on growth hormone secretion.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-13514258, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-13667431, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-13667432, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-13746229, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-13759343, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-13839500, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-13975313, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-14128852, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-14128853, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-14213659, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-16993603, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-4161422, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-4163545, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-4165177, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-4952849, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-4956516, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-4959003, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-4960823, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-5335536, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-5339250, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-5851958, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-5918931, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-5923699, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-5947603, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-5959019, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-6016624, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-6018576, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-6018752, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-6020215, http://linkedlifedata.com/resource/pubmed/commentcorrection/5653218-6026256
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1407-14
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1968
pubmed:articleTitle
Adrenergic receptor control mechanism for growth hormone secretion.
pubmed:publicationType
Journal Article