Linked Life Data

565270

Source:http://linkedlifedata.com/resource/pubmed/id/565270

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-4
pubmed:dateCreated
1978-6-28
pubmed:abstractText
Two strains of murine leukaemic lymphoblasts: L5178Y-R and L5178Y-S differing in the X-ray sensitivity by a factor of ca. 2 and showing X-ray-UV-light cross-sensitivity were exposed to: (a) 104 muCi/ml of HTO for time intervals from 25 to 600 h, (b) 10 muCi/ml of L-[4,5(n)-3H]lysine for 25 to 600 h, and (c) 0.05 muCi/ml of [methyl-3H] thymidine for 4 to 600 h. After completion of the exposure, survival was determined by cloning or by backward extrapolation of growth curves. In the case of HTO and 3H-thymidine exposure time the survival relationship passed through broad minima (75--200 and 50--400 h for (a) and (c), respectively). After longer exposures, higher survivals were observed reaching values close to 1 in the extreme cases. The results of shorter exposures indicate that L5178Y-R and L5178Y-S cells considerably differ in their susceptibilities to the tritiated compounds and that this difference increases with the shift of 3H localization towards DNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0011-3964
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-67
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Susceptibility of L5178Y-R and L5178Y-S cells to HTO, 3H-lysine and 3H-thymidine exposure.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S.