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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1977-11-30
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pubmed:abstractText |
Comparative study of peripheral nerve biopsies and cultured skin fibroblasts from patients with late infantile and early adult-onset forms of metachromatic leukodystrophy revealed similar pathologic changes in the early stages of nerve degeneration. However, the peripheral nerves in the adult-onset cases eventually reached a more chronically demyelinated fibrotic state than did nerves in the infantile cases. Cultured skin fibroblasts from the adult-onset patients, although clearly abnormal, were able to catabolize sulfatide significantly more effectively than the cultured skin fibroblasts from late infantile patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-3878
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
933-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:561906-Adolescent,
pubmed-meshheading:561906-Adult,
pubmed-meshheading:561906-Age Factors,
pubmed-meshheading:561906-Cells, Cultured,
pubmed-meshheading:561906-Child, Preschool,
pubmed-meshheading:561906-Female,
pubmed-meshheading:561906-Fibroblasts,
pubmed-meshheading:561906-Humans,
pubmed-meshheading:561906-Leukodystrophy, Metachromatic,
pubmed-meshheading:561906-Male,
pubmed-meshheading:561906-Myelin Sheath,
pubmed-meshheading:561906-Pedigree,
pubmed-meshheading:561906-Sural Nerve
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pubmed:year |
1977
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pubmed:articleTitle |
Metachromatic leukodystrophy: comparison of early-and late-onset forms.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|