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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1976-4-15
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pubmed:abstractText |
The synthetic terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) not only fails to elicit a GAT-specific antibody response in nonresponder mice, but also prior injection of GAT specifically decreases the ability of nonresponder mice to develop a GAT-specific antibody response to a subsequent challenge with GAT-MBSA. This inhibition is mediated by GAT-specific suppressor T cells. Further, a suppressive factor can be extracted from lymphoid cells of GAT-primed nonresponder mice that inhibits the development of primary GAT-specific antibody responses to GAT-MBSA and to GAT-PRBC- by normal syngeneic mice. The suppressive activity is dose-dependent and absorbed by GAT-Sepharose, but not by BSA-Sepharose. The suppressive activity elutes from a G-100 Sephadex column in the same fraction as ovalbumin, suggesting its m.w. is approximately 45,000 daltons.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-9
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pubmed:dateRevised |
2009-10-27
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pubmed:meshHeading |
pubmed-meshheading:55436-Animals,
pubmed-meshheading:55436-Antibody Formation,
pubmed-meshheading:55436-Cell-Free System,
pubmed-meshheading:55436-Epitopes,
pubmed-meshheading:55436-Hemolytic Plaque Technique,
pubmed-meshheading:55436-Immunosuppressive Agents,
pubmed-meshheading:55436-Lymphocytes,
pubmed-meshheading:55436-Mice,
pubmed-meshheading:55436-Mice, Inbred A,
pubmed-meshheading:55436-Mice, Inbred DBA,
pubmed-meshheading:55436-Molecular Weight,
pubmed-meshheading:55436-Oligopeptides,
pubmed-meshheading:55436-Peptides
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pubmed:year |
1976
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pubmed:articleTitle |
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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