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pubmed:otherAbstract |
PIP: The long-term (12 months) effects of a continuous daily dose (1.5 mcg per animal) of megestrol acetate on the physiology and biochemistry of the rat cervix is described. Megestrol acetate treatment resulted in a decline in dry matter, protein, lactic acid, and acid phosphatase activity. Glycogen, phospholipid, and alkaline phosphatase also diminished but the difference was not statistically significant. Megestrol acetate caused vertical disappearance of the superficial keratinized layers of the epithelium.
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