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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1971-4-6
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pubmed:abstractText |
1. Intracellular recording of the transmembrane potential in mouse pancreatic cells revealed a membrane potential of -20.1 +/- 0.8 mV for islet cells and -41.2 +/- 1.4 mV for acinar cells.2. The membrane potential of islet cells was glucose dependent and in the absence of glucose the cells hyperpolarized to -32.7 mV; with glucose 27.7 mM they depolarized to -16.1 mV.3. Above a threshold concentration of glucose (4 mM) small action potentials of amplitude 1-4 mV were induced in islet cells. The percentage of cells impaled exhibiting action potentials reached a maximum of 80% at 27.7 mM glucose.4. Mannose 16.6 mM was similar to glucose in its ability to induce action potential discharge in islet cells.5. 2,4-Dinitrophenol (0.25 mM) hyperpolarized islet cells and blocked electrical activity induced by glucose 11.1 mM.6. Adrenaline (1 muM) completely blocked glucose-induced electrical activity but without altering the membrane potential.7. The origin and functional significance of glucose-induced electrical activity in islet cells is discussed in relation to insulin secretion.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-13600411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-13605539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-13610875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-16992241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4290399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4301817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4387230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4863806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4864842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4870741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4873864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4878621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4879533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4891780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-4902715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-5320084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-5335536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-5501260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-5684032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-5807208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-6013145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5501259-6018752
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-64
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
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pubmed:year |
1970
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pubmed:articleTitle |
Glucose-induced electrical activity in pancreatic islet cells.
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pubmed:publicationType |
Journal Article
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