rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1976-4-2
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pubmed:abstractText |
Techniques for the amino acid sequence analysis of subnanomole quantities of polypeptides have been applied to characterize beta2-microglobulin and transplantation antigens of the mouse isolated from spleen cells by indirect immunoprecipitation. Eleven residues were identified throughout the NH2-terminal 27 residues of the beta2-microglobulin; all were identical to residues seen at the corresponding positions of beta2-microglobulins from other species. Two K and two D transplantation antigens were examined and the following generalizations emerged from the limited partial amino-acid sequence data: (1) the K and D molecules are homologous to one another; (2) they do not show amino acid sequence homology with immunoglobulins; (3) the two K and two D molecules differ from one another by multiple amino acid substitutions; and (4) the K molecules as a class cannot be distinguished from the D molecules as a class. The genetic and evolutionary implications of these observations are discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-1055432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-1059107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-1089744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-1134585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-1163764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-1172603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4098765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4106303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4108876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4113158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4124595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4134154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4134396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4139785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4185453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4507614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4525163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4586824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4598853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4613264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-46243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-46618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-47219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-48298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4833516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4841060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-4850708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-53836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-5461774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-813219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/54922-813561
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0027-8424
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
599-603
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:54922-Amino Acid Sequence,
pubmed-meshheading:54922-Animals,
pubmed-meshheading:54922-Beta-Globulins,
pubmed-meshheading:54922-Biological Evolution,
pubmed-meshheading:54922-Chromosome Mapping,
pubmed-meshheading:54922-Dogs,
pubmed-meshheading:54922-Histocompatibility Antigens,
pubmed-meshheading:54922-Humans,
pubmed-meshheading:54922-Mice,
pubmed-meshheading:54922-Species Specificity,
pubmed-meshheading:54922-Spleen,
pubmed-meshheading:54922-beta 2-Microglobulin
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pubmed:year |
1976
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pubmed:articleTitle |
Structure and evolution of transplantation antigens: partial amino-acid sequences of H-2K and H-2D alloantigens.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|