Linked Life Data

548252

Source:http://linkedlifedata.com/resource/pubmed/id/548252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1980-9-23
pubmed:abstractText
Mice exposed to a compound containing three phenol derivatives by being housed in cages washed with dilute solutions of the compound, developed considerable depression of the ability to generate plaque forming cells (PFC) in response to sheep erythrocytes (SRBC) in vitro after a four week exposure. The depression became more severe with continued exposure up to fourteen weeks. Administration of orthophenylphenol (OPP), the most abundant derivative in the mixture, resulted in a similar immunodepression at 10 ppm and a slight depression at 1 ppm. Numbers of FcR+ lymphocytes and of macrophages did not appear to be affected by this treatment. The response to a T-dependent and a T-independent antigen were affected similarly, although the latter was depressed less markedly than the former. While these data are only preliminary, they suggest that studies should be performed in detail to elucidate the immunodepressive effects of compounds which are in wide use as household and institutional disinfectants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-0545
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-77
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Phenol derivatives are immunodepressive in mice.
pubmed:publicationType
Journal Article