Linked Life Data

5480864

Source:http://linkedlifedata.com/resource/pubmed/id/5480864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1971-1-11
pubmed:abstractText
The importance of ceruloplasmin in iron metabolism was studied in swine made hypoceruloplasminemic by copper deprivation. When the plasma ceruloplasmin level fell below 1% of normal, cell-to-plasma iron flow became sufficiently impaired to cause hypoferremia, even though total body iron stores were normal. When ceruloplasmin was administered to such animals, plasma iron increased immediately and continued to rise at a rate proportional to the logarithm of the ceruloplasmin dose. The administration of inorganic copper induced increases in plasma iron only after ceruloplasmin appeared in the circulation. Thus, ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma. Studies designed to define the mechanism of action of ceruloplasmin were based on the in vitro observation that ceruloplasmin behaves as an enzyme (ferroxidase) that catalyzes oxidation of ferrous iron. Retention of injected ferrous iron in the plasma of ceruloplasmin-deficient swine was significantly less than that of ferric iron, reflecting impaired transferrin iron binding. Rat ceruloplasmin, which has little ferroxidase activity, was much less effective than porcine or human ceruloplasmin in inducing increases in plasma iron. These observations suggest that ceruloplasmin acts by virtue of its ferroxidase activity. Eight patients with Wilson's disease were evaluated in order to investigate iron metabolism in a disorder characterized by reduced ceruloplasmin levels. Evidence of iron deficiency was found in six of these, and in five of the six, plasma ceruloplasmin was less than 5% of normal. In comparison, the two patients without evidence of iron deficiency had ceruloplasmin levels of 11 and 18% of normal. It is suggested that iron deficiency tends to occur in those patients with Wilson's disease who have the severest degrees of hypoceruloplasminemia, possibly because of defective transfer of iron from intestinal mucosal cells to plasma.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-12997525, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-13278461, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-13319587, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-13332080, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-13739892, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-13808058, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-14376559, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-4308098, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-4961518, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5346295, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5455993, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5635941, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5675426, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5691595, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5791811, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5912351, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5916390, http://linkedlifedata.com/resource/pubmed/commentcorrection/5480864-5925868
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2408-17
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1970
pubmed:articleTitle
The role of ceruloplasmin in iron metabolism.
pubmed:publicationType
Journal Article