Linked Life Data

547069

Source:http://linkedlifedata.com/resource/pubmed/id/547069

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1980-8-15
pubmed:abstractText
Experiments in isolated left atria from rat hearts were performed in order to study the effects of stimulation rate on the transmembrane action potential. 1. Two components (fast and slow) of the action potential upstroke could be differentiated by adding MnCl2 to the perfusion solution. 2. With the increase in rate of stimulation over the control cycle length (500 msec), amplitude, Vmax and action potential duration at 80% of repolarization (D80) diminished in normal Krebs. In Mn-containing Krebs, only a slight reduction in amplitude was recorded. Resting potential and action potential duration at 20% (D20) and 50% (D50) of repolarization were only slightly affected in normal Krebs and not at all in Mn-Krebs. 3. Low rates of stimulation in normal Krebs increased D50 only slightly; however, D80 increased significantly while other parameters remained constant. No effects were seen in Mn-Krebs. 4. The results with Mn-Krebs indicate the importance of slow inward current on changes induced by stimulation rates. A possible mechanism relating intracellular calcium concentration and the outward K current, depending on the rate of stimulation, is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-7948
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
729-32
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Rate-dependent action potential changes in rat atrium.
pubmed:publicationType
Journal Article