Linked Life Data

545945

Source:http://linkedlifedata.com/resource/pubmed/id/545945

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1980-7-26
pubmed:abstractText
This paper presents the results of experiments on the in vitro effect of zinc ions on the affinity of hemoglobin for oxygen and on the 2,3-DPG content of the red blood cells of healthy humans. Blood was incubated in 1.5 X 10(-3) M ZnSO4 solution for 4 h and then the oxygen affinity of hemoglobin and the hematocrit number were determined. An original method of determination the oxygen dissociation curve of HbO2 was employed enabling an exact calculation of the P50 value of the hemolysates by the method of least squares. Analysis of statistically verified results reveals that zinc ions increase the oxygen affinity of hemoglobin bringing about a leftward shift of the HbO2 dissociation curve (by 3.85 mm Hg for P50) the level of 2,3-DPG remaining constant in the red cells incubated with ZnSO4. The mechanisms of this phenomenon and its possible clinical implications are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9661
pubmed:author
pubmed:issnType
Print
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
436-45
pubmed:dateRevised
2009-6-8
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Effect of zinc ions on the oxygen affinity of hemoglobin and the level of 2,3-DPG in normal human red blood cells in vitro.
pubmed:publicationType
Journal Article