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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1980-6-16
|
| pubmed:abstractText |
In animal studies, DL-[carboxyl-14C]tryptophan [DL-Try(C-14)] showed a high specificity for the pancreas, which suggested the potential of DL-[carboxyl-11C]tryptophan [DL-Try(C-11)] for clinical pancreatic inaging. The blood clearance and tissue uptake of the amino acid were very rapid, and no carrier effect was observed through a dose of 5 mg/kg. None of three transplanted hamster pancreatic adenocarcinomas that we studied showed a selective uptake of DL-Try(C-14) by the tumor, and none of the three enzymatic regimens investigated gave significant enhancement of the pancreatic specificity. Commercial L-Try(C-14) gave slightly better pancreatic specificity than the analogous racemic compound but without enough improvement to warrant attempts at optical resolution. DL-Try(C-11) was synthesized in amounts up to 325 mCi using a rapid, high-temperature, high-pressure modification of the Bücherer-Strecker amino acid synthesis. Yields ranged from 30--60%, and a total of 40 min was required for synthesis and chromatographic purification. DL-Try(C-11) thus appears to have significant potential as a clinical pancreas-imaging agent, particularly when used in conjunction with positron computerized transaxial tomography.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0161-5505
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
857-64
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:541734-Adenocarcinoma,
pubmed-meshheading:541734-Animals,
pubmed-meshheading:541734-Carbon Radioisotopes,
pubmed-meshheading:541734-Cholecystokinin,
pubmed-meshheading:541734-Cricetinae,
pubmed-meshheading:541734-Dogs,
pubmed-meshheading:541734-Female,
pubmed-meshheading:541734-Isotope Labeling,
pubmed-meshheading:541734-Male,
pubmed-meshheading:541734-Mesocricetus,
pubmed-meshheading:541734-Neoplasm Transplantation,
pubmed-meshheading:541734-Neoplasms, Experimental,
pubmed-meshheading:541734-Pancreas,
pubmed-meshheading:541734-Pancreatic Neoplasms,
pubmed-meshheading:541734-Rabbits,
pubmed-meshheading:541734-Rats,
pubmed-meshheading:541734-Secretin,
pubmed-meshheading:541734-Stimulation, Chemical,
pubmed-meshheading:541734-Tissue Distribution,
pubmed-meshheading:541734-Transplantation, Homologous,
pubmed-meshheading:541734-Tryptophan
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
DL-[Carboxyl-11C]tryptophan, a potential agent for pancreatic imaging; production and preclinical investigations.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|