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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1980-5-14
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pubmed:abstractText |
The vitamin K-dependent hemostatic factors are present in reduced quantities at birth and may decrease further in the first few days of life. Administration of vitamin K1 on day 1 prevents hemorrhagic disease of the newborn. Maternal ingestion of anticonvulsants puts the newborn at greater risk from hemorrhage, possibly as a result of induction of fetal microsomal enzymes with a resultant increased oxidative degradation of vitamin K which gives rise to a vitamin K deficiency and other concomitant clinical results, for example skeletal defects. Evidence for this sequence of events is presented and the widespread effect of vitamin K deficiency on the fetus is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0306-9877
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1347-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:537547-Abnormalities, Drug-Induced,
pubmed-meshheading:537547-Animals,
pubmed-meshheading:537547-Blood Coagulation Factors,
pubmed-meshheading:537547-Bone and Bones,
pubmed-meshheading:537547-Chick Embryo,
pubmed-meshheading:537547-Female,
pubmed-meshheading:537547-Hemostasis,
pubmed-meshheading:537547-Humans,
pubmed-meshheading:537547-Maternal-Fetal Exchange,
pubmed-meshheading:537547-Microsomes, Liver,
pubmed-meshheading:537547-Oxidation-Reduction,
pubmed-meshheading:537547-Phenytoin,
pubmed-meshheading:537547-Pregnancy,
pubmed-meshheading:537547-Vitamin K 1,
pubmed-meshheading:537547-Vitamin K Deficiency,
pubmed-meshheading:537547-Vitamin K Deficiency Bleeding,
pubmed-meshheading:537547-Warfarin
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pubmed:year |
1979
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pubmed:articleTitle |
Phenytoin, hemorrhage, skeletal defects and vitamin K in the newborn.
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pubmed:publicationType |
Journal Article
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