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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1980-5-14
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pubmed:abstractText |
The activity of the lysosomal enzymes of rat liver after a single intraperitoneal injection of methylmercuric chloride (5.0 mg/kg) was enhanced in the nuclear fraction during early post-injection (2 hr to 7 days), while it decreased in the mitochondrial fraction and increased in the lysosomal fraction during late post-injection (14 days). Rat brain activity, however, was reduced in the nuclear, mitochondrial and lysosomal fractions during late post-injection (14 days). A high accumulation of total mercury was observed in the liver during early post-injection (36 hr and 7 days) while similar accumulation in the brain occured during late post-injection (7 days and 14 days). Both the mercury burdens and the enzyme activities of the rat liver and brain returned to normal levels within 30 days.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0388-1350
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-10
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:537125-Animals,
pubmed-meshheading:537125-Brain,
pubmed-meshheading:537125-Enzymes,
pubmed-meshheading:537125-Liver,
pubmed-meshheading:537125-Lysosomes,
pubmed-meshheading:537125-Male,
pubmed-meshheading:537125-Mercury,
pubmed-meshheading:537125-Methylmercury Compounds,
pubmed-meshheading:537125-Rats,
pubmed-meshheading:537125-Time Factors,
pubmed-meshheading:537125-Tissue Distribution
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pubmed:year |
1979
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pubmed:articleTitle |
Effects of methylmercuric chloride intoxication on the intracellular activity of lysosomal enzymes in rat liver and brain.
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pubmed:publicationType |
Journal Article
|