Linked Life Data

535240

Source:http://linkedlifedata.com/resource/pubmed/id/535240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
144
pubmed:dateCreated
1980-5-14
pubmed:abstractText
Joint synovia and fluids taken from patients with various stages of rheumatoid arthritis (RA) were injected into embryonated chicken eggs, resulting in characteristic joint abnormalities ("crooked toes") in the extremities of the embryos and chicks. There was a direct correlation between the number of the induced lesions and the stages of the human RA disease. The percentage of abnormality of the bioassays was consistent with acute, subacute, chronic or remission phases in the clinical course of the RA disease. Specimens from chronic or remission RA joints produced few or no experimental abnormalities, suggesting few or no infectiojs RA particles available to the bioassay. Likewise, dilution of acute RA joint fluids of 1 : 100 by 0.15M NaCl resulted in a characteristic extinction of the bioassay test, suggesting that specimens could lose their reactivity in the bioassay because of too great dilution in the preparation of homogenates of the synovia. Numerical changes in the bioassay consistently followed the changes in the clinical courses of the RA during waning and waxing episodes. A useful numerical scale (0--100%) of the 10-day embryonated egg bioassay as an indication or measurement of the severity of the RA in the patient is proposed on the basis of these observations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-304
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Correlation of a bioassay with the clinical status of patients with rheumatoid arthritis.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.