Linked Life Data

5309489

Source:http://linkedlifedata.com/resource/pubmed/id/5309489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1970-5-16
pubmed:abstractText
Genetic recombination of influenza viruses provides the possibility of immediate reassortment and combination of genes and gene products in a single step. Thus, genetic variants with desirable attributes for vaccine production can be produced by deliberate genetic manipulation of viruses rather than by the empirical "hit or miss" methods of the past. Recombination of a high-yield laboratory strain (A0/PR/8) with a low-yield Hong Kong virus (Aichi strain) produced a high-yield recombinant virus (X-31) of Hong Kong antigenicity suitable for vaccine production. It is proposed that a prefabricated "library" of recombinants might anticipate the mutations which may arise in the future and also that live virus vaccines of greater stability may be produced by recombination of new and old viruses.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-9686
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
643-5
pubmed:dateRevised
2010-10-26
pubmed:meshHeading
pubmed:year
1969
pubmed:articleTitle
Future influenza vaccines and the use of genetic recombinants.
pubmed:publicationType
Journal Article