| pubmed-article:525980 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:525980 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:525980 | lifeskim:mentions | umls-concept:C0701159 | lld:lifeskim |
| pubmed-article:525980 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:525980 | lifeskim:mentions | umls-concept:C0008168 | lld:lifeskim |
| pubmed-article:525980 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:525980 | pubmed:dateCreated | 1980-3-24 | lld:pubmed |
| pubmed-article:525980 | pubmed:abstractText | The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin concentrations of </=1.5 mg/100 ml (3.57 +/- 1.72 ml/min per kg; P < 0.001). Serum protein binding of chloramphenicol was lower in cirrhotic patients (42.2 +/- 6.8% bound) than in normal adults (53.1 +/- 5.2% bound; P < 0.001). Low binding of chloramphenicol was also found in the serum of premature neonates (32.4 +/- 8.2% bound; P < 0.001). Reduced binding in neonates implies the need for a lower therapeutic range of total chloramphenicol concentration (3.5 to 13.9 mug/ml) compared with the usual adult range (5 to 20 mug/ml). Finally, three case reports are presented which demonstrate marked abnormalities and intrasubject variation in chloramphenicol clearance. | lld:pubmed |
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| pubmed-article:525980 | pubmed:language | eng | lld:pubmed |
| pubmed-article:525980 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:525980 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:525980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:525980 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:525980 | pubmed:month | May | lld:pubmed |
| pubmed-article:525980 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:525980 | pubmed:author | pubmed-author:KoupJ RJR | lld:pubmed |
| pubmed-article:525980 | pubmed:author | pubmed-author:SlaughterR... | lld:pubmed |
| pubmed-article:525980 | pubmed:author | pubmed-author:BrodskyBB | lld:pubmed |
| pubmed-article:525980 | pubmed:author | pubmed-author:LauA HAH | lld:pubmed |
| pubmed-article:525980 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:525980 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:525980 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:525980 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:525980 | pubmed:pagination | 651-7 | lld:pubmed |
| pubmed-article:525980 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:525980 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:525980 | pubmed:articleTitle | Chloramphenicol pharmacokinetics in hospitalized patients. | lld:pubmed |
| pubmed-article:525980 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:525980 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:525980 | pubmed:publicationType | Case Reports | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:525980 | lld:pubmed |
