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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1980-3-24
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pubmed:abstractText |
The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin concentrations of </=1.5 mg/100 ml (3.57 +/- 1.72 ml/min per kg; P < 0.001). Serum protein binding of chloramphenicol was lower in cirrhotic patients (42.2 +/- 6.8% bound) than in normal adults (53.1 +/- 5.2% bound; P < 0.001). Low binding of chloramphenicol was also found in the serum of premature neonates (32.4 +/- 8.2% bound; P < 0.001). Reduced binding in neonates implies the need for a lower therapeutic range of total chloramphenicol concentration (3.5 to 13.9 mug/ml) compared with the usual adult range (5 to 20 mug/ml). Finally, three case reports are presented which demonstrate marked abnormalities and intrasubject variation in chloramphenicol clearance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-1087110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-1242145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-13649107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-13762638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-13806261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-13843700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-14064991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-14284981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-4638972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-4825630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-5416851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-576637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-5821752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-6009827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-708020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-891592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-891593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/525980-950590
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
651-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
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pubmed:year |
1979
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pubmed:articleTitle |
Chloramphenicol pharmacokinetics in hospitalized patients.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
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