Linked Life Data

525845

Source:http://linkedlifedata.com/resource/pubmed/id/525845

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-3-17
pubmed:abstractText
It is possible to make an early diagnosis of rat " op " osteopetrosis. The growth of the mandibular incisor is stopped at birth by failure of bone resorption around the dental root. The primary trabeculae of the long bones fail to undergo resorption: osteoblasts differentiate along them, but osteoclasts are missing and reticular cells are not distinguishable. When 2 and 3 days old, the medullary cavity is obstructed by osseous trabeculae, vascular system is lacking, hemopoietic cells no longer differentiate, osteoclasts are scarce and degenerative; medullary tissue is compact, including numerous osteoblastic cells. Bone marrow smears clearly show medullary cell deficiency, weakening hemopoiesis, prevalent osteoblasts and a lack of osteoclasts. Marrow is taken out "in vivo" from an excised metatarsal bone, at birth and over the next few days. Osteopetrotic rats identified in this way in litters issued from heterozygote pair can be treated from the first week.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0003-3871
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
[Bones and bone marrow of the newborn " op " osteopetrotic rat, and the early diagnosis of the disease].
pubmed:publicationType
Journal Article, English Abstract