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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1980-3-17
|
| pubmed:abstractText |
For the development of the DES carcinoma syndrome, two different mechanisms may be assumed. 1. Indirect effect via teratogenesis: squamous cell carcinoma develops from adenosis vaginae with the assistance of cofactors (Fig. 6). Till now, a conversion of adenosis to clear cell carcinoma has never been observed (Hilgers, 1977). Adenosis is probably a precancerous lesion only for squamous cell carcinoma. 2. Transplacental terato-oncogenesis: clear cell carcinoma as a mesonephric carcinoma develops from persisting wolffian ducts with a latent period of 15 to 20 years. DES here acts only as a promoter by way of the transplacental teratogenic mechanism, thus as a terato-co-carcinogenic factor (Fig. 6).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0029-7828
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
814-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:523019-Abnormalities, Drug-Induced,
pubmed-meshheading:523019-Adenocarcinoma,
pubmed-meshheading:523019-Age Factors,
pubmed-meshheading:523019-Animals,
pubmed-meshheading:523019-Diethylstilbestrol,
pubmed-meshheading:523019-Female,
pubmed-meshheading:523019-Maternal-Fetal Exchange,
pubmed-meshheading:523019-Pregnancy,
pubmed-meshheading:523019-Rats
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
The stilbestrol-adenosis-carcinoma syndrome.
|
| pubmed:publicationType |
Journal Article
|